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Lin Chiun-Chin Associate Professor

Date of employment: Aug. 1, 2018
Magnetic resonance spectroscopy and imaging
Physical chemistry
TEL (O): (886-5) 272-0411 ext. 66418
B.S. in Applied Chemistry, National Chi Nan University, 2006
M.S. in Chemistry, National Chung Hsing University, 2008
Ph.D in Chemistry and Biochemistry, University of California, San Diego, 2015
Postdoc Fellow, Vanderbilt University Institute of Imaging Science, 2015-2018
Assistant Professor, National Chung Cheng University, 2018-
Research Interests
Developing techniques of magnetic
resonance spectroscopy and imaging
Studying membrane proteins with NMR
Diagnosis diseases with CEST (chemical exchange saturation transfer) MRI
Applications of biological and medical imaging 
Selected Publications 代表著作  [SCOPUS論文統計]
  •    Wu, W.-F.; Shen, C.-W; Lai, K.-M.; Chen, Y.-J.; Lin, E. C.*; Chen C.-C.*, “The Application of DTCWT on MRI-Derived Radiomics for Differentiation of Glioblastoma and Solitary Brain Metastases.” J. Pers. Med., 2022, 12(8), 1276
  •    Wu, Q.-X.; Liu, H.-Q.; Wang, Y.-J.; Chen, T.-C.; Wei, Z.-Y.; Chang, J.-H.; Chen, T.-H.; Seema, J.; Lin, E. C.* “Chemical Exchange Saturation Transfer (CEST) Signal at −1.6 ppm and Its Application for Imaging a C6 Glioma Model.” Biomedicines, 2022, 10(6), 1220
  •    Wu, S.‐T.; Chen, P.‐C.; Tseng, Y.‐H.; Chen, T.‐H.; Wang, Y.‐J.; Tsai, Z.‐L.; Tsai, Lin, E. C.*Assessment of Cellular Responses in Three‐Dimensional Cell Cultures Through Chemical Exchange Saturation Transfer and 1H Magnetic Resonance Spectroscopy.” NMR in Biomed., 2022, 35, e4757.
  •    Huang, Y.-T.; Su, Y.-C.; Wu, H.-R.; Huang, H.-H.; Lin, E. C.; Tsai, T.-W.; Tseng, H.-W.; Fang, J.-L.; Yu, C.-C. “Sulfo-Fluorous Tagging Strategy for Site-Selective Enzymatic Glycosylation of para-Human Milk Oligosaccharides.” ACS Catal., 2021, 11, 2631-2643
  •    Zu, Z.; Lin, E. C.; Louie, E. A.; Jiang, X; Lankford, C. L.; Damon, B.; Does, M. D.; Gore, J. C.; Gochberg, D. F. “Chemical exchange rotation transfer imaging of phosphocreatine in muscle.” NMR in Biomed., 2021, 34, e4437.
  •    Chen, Y.-W.; Liu, H.-Q.; Wu, Q.; Huang, Y.-H.; Tung, Y.-Y.; Lin, M.-H.; Lin, C.-H.; Chen, T.-C.; Lin, E. C.; Hwang, D. W. “pH Mapping of Skeletal Muscle by Chemical Exchange Saturation Transfer (CEST) Imaging.” Cells, 2020, 9, 2610.
  •    Wen, X.; Ou, Y.-C.; Bogatcheva, G.; Thomas, G.; Mahadevan-Jansen, A.; Singh, B.; Lin, E. C.; Bardhan, R. “Probing metabolic alterations in breast cancer in response to molecular inhibitors with Raman spectroscopy and validated with mass spectrometry.” Chem. Sci. 2020, 11, 9863-9874.
  •    Chang, Y.‐C.; Liu, H.‐Q.; Chang, J.‐H.; Chang, Y.‐Y.; Lin, E. C. Role of the cholesterol hydroxyl group in the chemical exchange saturation transfer signal at − 1.6 ppm. NMR in Biomed., 2020, 33, e4356.
  •    Wen, X.; Ou, Y.‐C.; Zarick, H. F.; Zhang, X.; Hmelo, A. B.; Victor, Q. J.; Paul, E. P.; Slocik, J. M.; Naik, R. R.; Bellan, L. M.; Lin, E. C.; Bardhan R. PRADA: Portable Reusable Accurate Diagnostics with nanostar Antennas for Multiplexed Biomarker Screening. Bioeng. Transl. Med., 2020, e10165.
  •    Zu, Z.; Lin, E. C.; Louie, E. A.; Xu, J.; Li, H.; Xie, J.; Lankford, C. L.; Chekmenev, E. Y.; Swanson, S. D.; Does, M. D.; Gore, J. C.; Gochberg, D. F. Relayed nuclear Overhauser enhancement sensitivity to membrane Cho phospholipids. Magn. Reson. Med. 2020, 84, 1961-1976.
  •    Ou, Y.-C.; Wen, X.; Johnson, C. A.; Shae, D.; Ayala, O. D.; Webb, J. A.; Lin, E. C.; DeLapp, R. C.; Boyd, K. L.; Richmond, A.; Mahadevan-Jansen, A.; Rafat, M.; Wilson, J. T.; Balko, J. M.; Tantawy, M. N.; Vilgelm, A. E.; Bardhan, R. Multimodal multiplexed immunoimaging with nanostars to detect multiple immunomarkers and monitor response to immunotherapies. ACS nano, 2019, 14, 651-663.
  •    Ou, Y.-C.; Webb, J. A.; OBrien, C. M.; Pence, I. J.; Lin, E. C.; Paul, E. P.; Cole, D.; Ou, S.-H.; Lapierre-Landry, M.; DeLapp, R. C.; Lippmann, E. S.; Mahadevan-Jansen, A.; Bardhan R. Diagnosis of immunomarkers in vivo via multiplexed surface enhanced Raman spectroscopy with gold nanostars. Nanoscale. 2018, 10, 13092-13105.
  •    Lin, E. C.; Li, H.; Zu, Z.; Lankford, C. L.; Dortch, R. D.; Gore, J. C.; Gochberg D. F. Chemical exchange rotation transfer (CERT) on human brain at 3 Tesla. Magn. Reson. Med. 2018, 80, 2609-2617.
  •    Zhang, C.; Idelbayev, Y.; Tao, Y.; Duggan, B. M.; Lin, E. C.; Gerwick, E. C.; Cottrell, G. W.; Gerwick, W. H. Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Research. Sci. Rep. 20177, 14243.
  •    Webb, J. A.; Ou, Y.-C.; Faley, S.; Hittinger, J.; Cutright, C. C.; Lin, E. C.; Bellan, L. M.; Bardhan, R. Theranostic Gold Nanoantennas for Simultanoeus Multiplexed Raman Imaging and Photothermal Therapy. ACS Omega 20172, 3583-3594.
  •    Zhang, X.-Y.; Xie, J.; Wang, F.; Lin, E. C.; Xu, J.; Gochberg, D. F.; Gore, J. C.; Zu, Z. Assignment of the molecular origins of CEST signals at 2 ppm in rat brain. Magn. Reson. Med. 201778, 881-887.
  •    Zu, Z.; Louie, E. A.; Lin, E. C.; Jiang, X.; Does, M. D.; Gore, J. C.; Gochberg, D. F. Chemical Exchange Rotation Transfer Imaging of Intermediate Exchanging Amines at 2 ppm. NMR in Biomed. 201730, e3756.
  •    Zhang, H.; Lin, E. C.; Das, B. B.; Tian, Y.; Opella, S. J. Structural determination of virus protein U from HIV-1 by NMR in membrane environments. BBA-BIOMEMBRANES 20151848, 3007-3018.
  •    Lin, E. C.; Opella, S. J. Covariance Spectroscopy in High-Resolution Multi-dimensional Solid-state NMR. J. Magn. Reson. 2014239, 57-60.
  •    Lin, E. C.; Opella, S. J. Sampling Scheme and Compressed Sensing Applied to Solid-State NMR Spectroscopy. J. Magn. Reson. 2013237, 40-48.
  •    Das, B. B.; Lin, E. C.; Opella, S. J. Experiments Optimized for Magic Angle Spinning and Oriented Sample Solid-State NMR of Proteins. J. Phys. Chem. B 2013117, 12422-12431.
  •    Hsu, C.-C.; White, N. M.; Hayashi, M.; Lin, E. C.; Poon, T.; Banerjee, I.; Chen, J.; Pfaff, S. L.; Macagno, E. R.; Dorrestein, P. C. Microscopy ambient ionization top-down mass spectrometry reveals developmental patterning. Proc. Natl. Acad. Sci. U. S. A. 2013110, 14855-14860.
  •    Chien, M.-P.; Thompson, M. P.; Lin, E. C.; Gianneschi, N. C. Fluorogenic Enzyme-Responsive Micellar Nanoparticles. Chem. Sci. 20123, 2690-2694.
  •    Lin, E. C.; Opella, S. J. 1H assisted 13C/15N heteronuclear correlation spectroscopy in oriented sample solid-state NMR of single crystal and magnetically aligned samples. J. Magn. Reson. 2011211, 37-44.
  •    Lin, E. C.; Wu, C. H.; Yang, Y.; Grant, C. V.; Opella, S. J. 1H-13C separated local field spectroscopy of uniformly 13C labeled peptides and proteins. J. Magn. Reson. 2010206, 105-111. 
  •    Tang, H.-Y.; Lin, C.-C.; Wang, L.-S.; Yang, W.-C.; Liao, K.-H.; Li, F.-Y.; Liao, M. Y. Quantum size effect on 67Zn-NMR measurements of ZnS nanoparticles. Phys. Rev. B 200877, 165420-165425.




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