Lin Chiun-Chin Associate Professor

Date of employment: Aug. 1, 2018 Specialty: Magnetic resonance spectroscopy and imaging Physical chemistry Biophysics TEL (O): (886-5) 272-0411 ext. 66418 Email:cheel@ccu.edu.tw Lab Webpage
B.S. in Applied Chemistry, National Chi Nan University, 2006 M.S. in Chemistry, National Chung Hsing University, 2008 Ph.D in Chemistry and Biochemistry, University of California, San Diego, 2015 Postdoc Fellow, Vanderbilt University Institute of Imaging Science, 2015-2018 Assistant Professor, National Chung Cheng University, 2018-
Research Interests Developing techniques of magnetic resonance spectroscopy and imaging Studying membrane proteins with NMR Diagnosis diseases with CEST (chemical exchange saturation transfer) MRI Applications of biological and medical imaging
Selected Publications 代表著作 [SCOPUS論文統計] Wu, W.-F.; Shen, C.-W; Lai, K.-M.; Chen, Y.-J.; Lin, E. C.; Chen C.-C., “The Application of DTCWT on MRI-Derived Radiomics for Differentiation of Glioblastoma and Solitary Brain Metastases.” J. Pers. Med., 2022, 12(8), 1276 Wu, Q.-X.; Liu, H.-Q.; Wang, Y.-J.; Chen, T.-C.; Wei, Z.-Y.; Chang, J.-H.; Chen, T.-H.; Seema, J.; Lin, E. C.* “Chemical Exchange Saturation Transfer (CEST) Signal at −1.6 ppm and Its Application for Imaging a C6 Glioma Model.” Biomedicines, 2022, 10(6), 1220 Wu, S.‐T.; Chen, P.‐C.; Tseng, Y.‐H.; Chen, T.‐H.; Wang, Y.‐J.; Tsai, Z.‐L.; Tsai, Lin, E. C.* “Assessment of Cellular Responses in Three‐Dimensional Cell Cultures Through Chemical Exchange Saturation Transfer and ¹H Magnetic Resonance Spectroscopy.” NMR in Biomed., 2022, 35, e4757. Huang, Y.-T.; Su, Y.-C.; Wu, H.-R.; Huang, H.-H.; Lin, E. C.; Tsai, T.-W.; Tseng, H.-W.; Fang, J.-L.; Yu, C.-C. “Sulfo-Fluorous Tagging Strategy for Site-Selective Enzymatic Glycosylation of para-Human Milk Oligosaccharides.” ACS Catal., 2021, 11, 2631-2643 Zu, Z.; Lin, E. C.; Louie, E. A.; Jiang, X; Lankford, C. L.; Damon, B.; Does, M. D.; Gore, J. C.; Gochberg, D. F. “Chemical exchange rotation transfer imaging of phosphocreatine in muscle.” NMR in Biomed., 2021, 34, e4437. Chen, Y.-W.; Liu, H.-Q.; Wu, Q.; Huang, Y.-H.; Tung, Y.-Y.; Lin, M.-H.; Lin, C.-H.; Chen, T.-C.; Lin, E. C.; Hwang, D. W. “pH Mapping of Skeletal Muscle by Chemical Exchange Saturation Transfer (CEST) Imaging.” Cells, 2020, 9, 2610. Wen, X.; Ou, Y.-C.; Bogatcheva, G.; Thomas, G.; Mahadevan-Jansen, A.; Singh, B.; Lin, E. C.; Bardhan, R. “Probing metabolic alterations in breast cancer in response to molecular inhibitors with Raman spectroscopy and validated with mass spectrometry.” Chem. Sci. 2020, 11, 9863-9874. Chang, Y.‐C.; Liu, H.‐Q.; Chang, J.‐H.; Chang, Y.‐Y.; Lin, E. C. 「Role of the cholesterol hydroxyl group in the chemical exchange saturation transfer signal at − 1.6 ppm.」 NMR in Biomed., 2020, 33, e4356. Wen, X.; Ou, Y.‐C.; Zarick, H. F.; Zhang, X.; Hmelo, A. B.; Victor, Q. J.; Paul, E. P.; Slocik, J. M.; Naik, R. R.; Bellan, L. M.; Lin, E. C.; Bardhan R. 「PRADA: Portable Reusable Accurate Diagnostics with nanostar Antennas for Multiplexed Biomarker Screening.」 Bioeng. Transl. Med., 2020, e10165. Zu, Z.; Lin, E. C.; Louie, E. A.; Xu, J.; Li, H.; Xie, J.; Lankford, C. L.; Chekmenev, E. Y.; Swanson, S. D.; Does, M. D.; Gore, J. C.; Gochberg, D. F. 「Relayed nuclear Overhauser enhancement sensitivity to membrane Cho phospholipids.」 Magn. Reson. Med. 2020, 84, 1961-1976. Ou, Y.-C.; Wen, X.; Johnson, C. A.; Shae, D.; Ayala, O. D.; Webb, J. A.; Lin, E. C.; DeLapp, R. C.; Boyd, K. L.; Richmond, A.; Mahadevan-Jansen, A.; Rafat, M.; Wilson, J. T.; Balko, J. M.; Tantawy, M. N.; Vilgelm, A. E.; Bardhan, R. 「Multimodal multiplexed immunoimaging with nanostars to detect multiple immunomarkers and monitor response to immunotherapies.」 ACS nano, 2019, 14, 651-663. Ou, Y.-C.; Webb, J. A.; O』Brien, C. M.; Pence, I. J.; Lin, E. C.; Paul, E. P.; Cole, D.; Ou, S.-H.; Lapierre-Landry, M.; DeLapp, R. C.; Lippmann, E. S.; Mahadevan-Jansen, A.; Bardhan R. 「Diagnosis of immunomarkers in vivo via multiplexed surface enhanced Raman spectroscopy with gold nanostars.」 Nanoscale. 2018, 10, 13092-13105. Lin, E. C.; Li, H.; Zu, Z.; Lankford, C. L.; Dortch, R. D.; Gore, J. C.; Gochberg D. F. 「Chemical exchange rotation transfer (CERT) on human brain at 3 Tesla.」 Magn. Reson. Med. 2018, 80, 2609-2617. Zhang, C.; Idelbayev, Y.; Tao, Y.; Duggan, B. M.; Lin, E. C.; Gerwick, E. C.; Cottrell, G. W.; Gerwick, W. H. 「Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Research.」 Sci. Rep. 2017, 7, 14243. Webb, J. A.; Ou, Y.-C.; Faley, S.; Hittinger, J.; Cutright, C. C.; Lin, E. C.; Bellan, L. M.; Bardhan, R. 「Theranostic Gold Nanoantennas for Simultanoeus Multiplexed Raman Imaging and Photothermal Therapy.」 ACS Omega 2017, 2, 3583-3594. Zhang, X.-Y.; Xie, J.; Wang, F.; Lin, E. C.; Xu, J.; Gochberg, D. F.; Gore, J. C.; Zu, Z. 「Assignment of the molecular origins of CEST signals at 2 ppm in rat brain.」 Magn. Reson. Med. 2017, 78, 881-887. Zu, Z.; Louie, E. A.; Lin, E. C.; Jiang, X.; Does, M. D.; Gore, J. C.; Gochberg, D. F. 「Chemical Exchange Rotation Transfer Imaging of Intermediate Exchanging Amines at 2 ppm.」 NMR in Biomed. 2017, 30, e3756. Zhang, H.; Lin, E. C.; Das, B. B.; Tian, Y.; Opella, S. J. 「Structural determination of virus protein U from HIV-1 by NMR in membrane environments.」 BBA-BIOMEMBRANES 2015, 1848, 3007-3018. Lin, E. C.; Opella, S. J. 「Covariance Spectroscopy in High-Resolution Multi-dimensional Solid-state NMR.」 J. Magn. Reson. 2014, 239, 57-60. Lin, E. C.; Opella, S. J. 「Sampling Scheme and Compressed Sensing Applied to Solid-State NMR Spectroscopy.」 J. Magn. Reson. 2013, 237, 40-48. Das, B. B.; Lin, E. C.; Opella, S. J. 「Experiments Optimized for Magic Angle Spinning and Oriented Sample Solid-State NMR of Proteins.」 J. Phys. Chem. B 2013, 117, 12422-12431. Hsu, C.-C.; White, N. M.; Hayashi, M.; Lin, E. C.; Poon, T.; Banerjee, I.; Chen, J.; Pfaff, S. L.; Macagno, E. R.; Dorrestein, P. C. 「Microscopy ambient ionization top-down mass spectrometry reveals developmental patterning.」 Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 14855-14860. Chien, M.-P.; Thompson, M. P.; Lin, E. C.; Gianneschi, N. C. 「Fluorogenic Enzyme-Responsive Micellar Nanoparticles.」 Chem. Sci. 2012, 3, 2690-2694. Lin, E. C.; Opella, S. J. 「¹H assisted ¹³C/¹⁵N heteronuclear correlation spectroscopy in oriented sample solid-state NMR of single crystal and magnetically aligned samples.」 J. Magn. Reson. 2011, 211, 37-44. Lin, E. C.; Wu, C. H.; Yang, Y.; Grant, C. V.; Opella, S. J. 「¹H-¹³C separated local field spectroscopy of uniformly ¹³C labeled peptides and proteins.」 J. Magn. Reson. 2010, 206, 105-111. Tang, H.-Y.; Lin, C.-C.; Wang, L.-S.; Yang, W.-C.; Liao, K.-H.; Li, F.-Y.; Liao, M. Y. 「Quantum size effect on ⁶⁷Zn-NMR measurements of ZnS nanoparticles.」 Phys. Rev. B 2008, 77, 165420-165425.