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Chu Yen-Ho Professor


Date of employmentAug. 1, 1999

Bioorganic Chemistry
Synthetic Organic Chemistry
Combinatorial Chemistry

TEL (O)(886-5) 272-0411 ext. 66408


Lab Webpage



B.S. in Chemistry, National Tsing Hua University, 1979

M.S. in Chemistry, National Taiwan University, 1984

Ph. D. in  Harvard University, 1993

Postdoc Researcher, Harvard Medical school, 1993-1994

Staff Scientist, Northeastern University, 1994-1995

Assistant Professor, the Ohio State University, 1995-1999

Associate Professor, National Chung Cheng Univ., 1999-2008

Professor, National Chung Cheng Univ., 2008-


Research Interests

Biomolecular Recognition: Surface Plasmon

Resonance and Quartz Crystal Microbalance

Combinatorial Organic Synthesis: Natural Product and Protein Inhibitor Synthesis Ionic Liquids for Chemical and Biochemical Applications




Selected Publications 代表著作  [SCOPUS論文統計]

  • Huang, H.-H.; Jia, J.; Ren, L.; Wang, S.; Yue, T.;* Yan, B.;* Chu, Y.-H.* "A Zwitterionic Solution for Smart Ionic Liquids to Evade Cytotoxicity", J. Hazard. Mater. 2023, 453, 131430; DOI: 10.1016/j.jhazmat.2023.131430.
  • Chu, Y.-H.;* Chen, P.-H.; Huang, H.-H. "Exploiting a-Benzylated 1,4-Butanesultones to Expedite the Discovery of Small-Molecule, LCST-type Sulfobetaine Zwitterionic Materials", Mater. Adv. 2023, 4, 1740-1745.
  • Chu, Y.-H.;* Chen, C.-Y.; Chen, J.-S. "Structural Engineering and Optimization of Zwitterionic Salts for Expeditious Discovery of Thermoresponsive Materials", Molecules 2022, 27, 257; DOI: 10.3390/molecules27010257.
  • Pan, X.; Li, L.; Huang, H.-H.; Wu, J.; Zhou, X.; Yan, X.; Jia, J.; Yue, T.;* Chu, Y.-H.;* Yan, B.* "Biosafety-Inspired Structural Optimization of Triazolium Ionic Liquids Based on Structure-Toxicity Relationships", J. Hazard. Mater. 2022, 424, 127521; DOI: 10.1016/j.jhazmat.2021.127521.
  • Wei, P.; Pan, X.; Chen, C.-Y.; Li, H.-Y.; Yan, X.; Li, C.; Chu, Y.-H.;* Yan, B.* "Emerging Impacts of Ionic Liquids on Eco-Environmental Safety and Human Health", Chem. Soc. Rev. 2021, 50, 13609-13627; DOI: 10.1039/d1cs00946j.
  • Chu, Y.-H.;* Chen, C.-Y. "Structural Fine-tuning of Zwitterionic Salts for the Discovery of LCST-type Thermoresponsive Materials", Mater. Chem. Front. 2021, 5, 7286–7290.
  • Chu, Y.-H.*; Cheng, M.-F.; Chiang, Y.-H. "Combinatorial Discovery of Small-Molecule 1,2,3-Triazolium Ionic Liquids Exhibiting Lower Critical Solution Temperature Phase Transition", Sci. Rep. 2020, 10, 18247; DOI: 10.1038/s41598-020-75392-z. 
  • Chu, Y.-H.*; Hwang, C.-C.; Chen, C.-Y.; Tseng, M.-J. "Combinatorial Discovery of Thermoresponsive Cycloammonium Ionic Liquids", Chem. Commun. 2020, 56, 11855 – 11858.
  • Li, H.-Y.; Chu, Y.-H.* "Reaction-Based Amine and Alcohol Gases Detection with Triazine Ionic Liquid Materials", Molecules 2020, 25, 104; doi:10.3390/molecules25010104.
  • Chang, A.; Li, H.-Y.; Chang, I.-N.; Chu, Y.-H.* "Affinity Ionic Liquids for Chemoselective Gas Sensing", Molecules 201823, 2380; doi:10.3390/molecules23092380. 
  • Chen, C.-Y.; Li, K.-H.; Chu, Y.-H.* "Reactions-Based Detection of Chemical Warfare Agent Mimics with Affinity Ionic Liquids", Anal. Chem. 201890, 8320-8325.
  • Chang, Y.-P.; Chu, Y.-H.* Recognition-Based Smart Ionic Liquids, In Ionic Liquid Devices; Eftekhari, A., Ed.; The Royal Society of Chemistry: Cambridge, UK, 2017; Chapter 10.
  • Li, H.-Y.; Chu, Y.-H.* "Exploiting Solvate Ionic Liquids for Amine Gas Analysis on a Quartz Crystal Microbalance", Anal. Chem. 201789, 5186-5192.
  • Tseng, M.-C.; Yuan, T.-C.; Li, Z.; Chu, Y.-H.* "Crowned Ionic Liquids for Biomolecular Interaction Analysis", Anal. Chem201688, 10811-10815.
  • Hsu, T.-H.; Chiang, S.-J.; Chu, Y.-H.* "Quartz Crystal Microbalance Analysis of Diels-Alder Reactions of Alkene Gases to Functional Ionic Liquids on Chips", Anal. Chem201688, 10837-10841.
  • Li, H.-Y.; Chen, C.-Y.; Cheng, H.-T.; Chu, Y.-H.* "Exploiting Bicyclic 1,2,3-Triazolium Ionic Liquids for Synthesis of Tryptanthrin and Chemoselective Extraction of Copper(II) Ion and Histidine Containing Peptides", Molecules 2016, 21, 1355.
  • Chang, Y.-P.; Chu, Y.-H.* "Gas Sensing Ionic Liquids on Quartz Crystal Microbalance", Ionic Liquids (Hardy, S., Ed.); InTech: Croatia, EU, 2016 (ISBN 978-953-51-4897-5).
  • Chang, Y.-P., Liu, W.-C.; Tseng, M.-C.; Chu, Y.-H.* "Ionic Liquids Tailored for Reaction-Based Gas Sensing on Quartz Crystal Microbalance", Rev. Anal. Chem. 201534, 77-86.
  • Li, H.-Y.; Hsu, T.-H.; Chen, C.-Y.; Tseng, M.-C.; Chu, Y.-H.* "Exploring Silver Ionic Liquids for Reaction-Based Gas Sensing on Quartz Crystal Microbalance", Analyst 2015140, 6245-6249.
  • Chang, Y.-P.; Chu, Y.-H.* Mixture-based combinatorial libraries from small individual peptide libraries: A Case Study on α1-Antitrypsin DeficiencyMolecules 201419, 6330-6348.
  • Tseng, M.-C.; Lai, P.-Y.; Shi, L.; Li, H.-Y.; Tseng, M.-J.; Chu, Y.-H. Synthesis of Batracylin and N-Sulfonamido Analogues in [b-3C-im][NTf2] Ionic LiquidTetrahedron 201470, 2629-2633.
  • Tseng, M.-C.; Chu, Y.-H. Reaction-Based Azide Gas Sensing with Tailored Ionic Liquids Measured by Quartz Crystal MicrobalanceAnal. Chem201486, 1949-1952.
  • Chang, Y.-P.; Chu, Y.-H. Blocking Formation of Large Protein Aggregates by Small PeptidesChem. Commun201349, 4591-4600.
  • Liu, Y.-L.; Tseng, M.-C.; Chu, Y.-H. Sensing Ionic Liquids for Chemoselective Detection of Acyclic and Cyclic Ketone GasesChem. Commun. 201349, 2560-2562.
  • Shi, Y.; Liu, Y.-L.; Lai, P.-Y.; Tseng, M.-C.; Tseng, M.-J.; Li, Y.; Chu, Y.-H. "Ionic Liquids Promote PCR Amplification of DNA", Chem. Commun201248, 5325-5327.
  • Cheng, C. I.; Chang, Y.-P.; Chu, Y.-H. "Biomolecular Interactions and Tools for Their Recognition: Focus on the Quartz Crystal Microbalance and Its Diverse Surface Chemistries and Applications", Chem. Soc. Rev201241, 1947-1971.
  • Sowmiah, S.; Cheng, C. I.; Chu, Y.-H. "Ionic Liquids for Green Organic Synthesis", Curr. Org. Syn. 20128, 74-95.
  • Tseng, M.-C.; Cheng, H.-T.; Shen, M.-J.Chu, Y.-H. Bicyclic 1,2,3-Triazolium Ionic Liquids: Synthesis, Characterization, and Application to Rutaecarpine SynthesisOrg. Lett. 201113, 4434-4437.
  • Chen, C.-W.; Tseng, M.-C.; Hsiao, S.-K.; Chen, W.-H.; Chu, Y.-H. "Transimination Reactions in [b-3C-im][NTf2] Ionic Liquid", Org. Biomol. Chem. 20119, 4188-4193.
  • Tseng, M.-C.; Chu, Y.-W.; Tsai, H.-P.; Lin, C.-M.; Hwang, J.Chu, Y.-H. One-Pot Synthesis of Luotonin A and Its AnaloguesOrg. Lett. 201113, 920-923.
  • Tseng, M.-C.; Chu, Y.-H. "Chemoselective Gas Sensing Ionic Liquids", Chem. Commun. 201046, 2983-2985.
  • Tseng, M.-C.; Yang, H.-Y.; Chu, Y.-H. "Total Synthesis of Asperlicin C, Circumdatin F, Demethylbenzomalvin A, Demethoxycircumdatin H, Sclerotigenin, and Other Fused Quinazolinones", Org. Biomol. Chem. 20108, 419-427.
  • Tseng, M.-C.; Tseng, M.-J.; Chu, Y.-H. "Affinity Ionic Liquid", Chem. Commun. 2009, 7503-7505.
  • Sowmiah, S.; Srinivasadesikan, V.; Tseng, M.-C.; Chu, Y.-H. "On the Chemical Stabilities of Ionic Liquids" (invited review), Molecules 200914, 3780-3813.
  • Tseng, M.-C.; Lai, C.-Y.; Chu, Y.-W.; Chu, Y.-H. "Tin Triflate-Mediated Total Syntheses of Circumdatin F, Asperlicin C, Sclerotigenin, and Other Quinazolino[3,2-a][1,4]benzodiazepines", Chem. Commun. 2009, 445-447.
  • Chang, Y.-P.; Mahadeva, R.; Chang, W.-S. W.; Lin, S.-C.; Chu, Y.-H. "Small-Molecule Peptides Inhibit Z α1-Antitrypsin Polymerization ", J. Cell. Mol. Med. 200913, 2304-2316.
  • Tseng, M.-C.; Chu, Y.-H. "Zinc Triflate-Catalyzed Synthesis of Pyrazino[2,1-b]quinazoline-3,6-diones", Tetrahedron 200864, 9515-9520.
  • Tseng, M.-C.; Kan, H.-C,; Chu, Y.-H. "Reactivity of Trihexyl(tetradecyl)phosphonium Chloride, a Room-Temperature Phosphonium Ionic Liquid", Tetrahedron Lett. 200748, 9085-9089.
  • Lin, Y.-L.; Cheng, J.-Y.; Chu, Y.-H. "Microwave-Accelerated Claisen Rearrangement in Bicyclic Imidazolium [b-3C-im][NTf2] Ionic Liquid", Tetrahedron 200763, 10949-10957.
  • Tseng, M.-C.; Chang, Y.-P.; Chu, Y.-H. "Quantitative Measurements of Vancomycin Binding to Self-Assembled Peptide Monolayers on Chips by Quartz Crystal Microbalance", Anal. Biochem. 2007371, 1-9.
  • Kan, H.-C,; Tseng, M.-C.; Chu, Y.-H. "Bicyclic Imidazolium-Based Ionic Liquids: Synthesis and Characterization", Tetrahedron. 200763, 1644-1653.
  • 張怡斌、曾明中、朱延和 「生醫感測科技於新藥開發的應用」科儀新知 200728, 56-67.
  • Chang, Y.-P.; Tseng, M.-J.; Chu, Y.-H. "Using Surface Plasmon Resonance to Directly Measure Slow Binding of Low Molecular Mass Inhibitors to a VanX Chip", Anal. Biochem. 2006359, 63-71.
  • Hsieh, M.-L.; Tseng, M.-J.; Tseng, M.-C.; Chu, Y.-H. "Identification of a New Chromophoric Substrate in the Library of Amino Acid p-Nitroanilides for Continuous Assay of VanX, a D, D-Dipeptidase Essential for Vancomycin Resistance", Anal. Biochem. 2006354, 104-110.
  • Cheng, J.-Y.; Chu, Y.-H. "1-Butyl-2,3-trimethyleneimidazolium Bis(trifluoromethylsulfonyl)imide ([b-3C-im][NTf2]): A New, Stable Ionic Liquid", Tetrahedron Lett. 200647, 1575-1579.
  • Chang, Y.-P.; Mahadeva, R.; Chang, W.-S. W.; Shukla, A.; Dafforn, T. R.; Chu, Y.-H. "Identification of a 4-mer Peptide Inhibitor that Effectively Blocks the Polymerization of Pathogenic Z a1-Antitrypsin", Am. J. Respir. Cell Mol. Biol. 200635, 540-548.
  • 張怡斌、張文祥、朱延和 "a1-抗胰蛋白酶缺乏癥與蛋白質構型變異疾病", 化學 200563, 419-430.
  • Cheng, C. I.; Chang, Y.-P.; Chu, Y.-H. "Inhibition of the Pathogenic Polymerization of Z α1-antitrypsin by 4-mer Peptides", Proceedings of the TTT2005 Academic Conference, pp. 8-13 (2005).
  • Tseng, M.-C.; Liang, Y.-M.; Chu, Y.-H. "Synthesis of Fused Tetrahydro-b-carbolinequinoxalinones in 1-n-Butyl-2,3-dimethylimidazolium Bis(trifluoromethylsulfonyl)imide ([bdmim][Tf2N]) and 1-n-Butyl-2,3-dimethylimidazolium Perfluorobutylsulfonate ([bdmim][PFBuSO3]) Ionic Liquids", Tetrahedron Lett. 200546, 6131-6136.
  • Chang, Y.-P.; Chu, Y.-H. "Using Surface Plasmon Resonance to Directly Determine Binding Affinities of Combinatorially Selected Cyclopeptides and Their Linear Analogs to a Streptavidin Chip", Anal. Biochem. 2005340, 74-79.
  • Tseng, M.-C.; Chu, Y.-H. "Using Surface Plasmon Resonance to Directly Identify Molecules in a Tripeptide Library that Bind Tightly to Immobilized Vancomycin", Anal. Biochem. 2005336, 172-177.



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