Chu Yen-Ho Professor

　　

Date of employment: Aug. 1, 1999

Specialty: 
Bioorganic Chemistry
Synthetic Organic Chemistry
Combinatorial Chemistry

TEL (O): (886-5) 272-0411 ext. 66408

Email: cheyhc@ccu.edu.tw

Lab Webpage

　

  

B.S. in Chemistry, National Tsing Hua University, 1979

M.S. in Chemistry, National Taiwan University, 1984

Ph. D. in  Harvard University, 1993

Postdoc Researcher, Harvard Medical school, 1993-1994

Staff Scientist, Northeastern University, 1994-1995

Assistant Professor, the Ohio State University, 1995-1999

Associate Professor, National Chung Cheng Univ., 1999-2008

Professor, National Chung Cheng Univ., 2008-

 

Research Interests

Biomolecular Recognition: Surface Plasmon

Resonance and Quartz Crystal Microbalance

Combinatorial Organic Synthesis: Natural Product and Protein Inhibitor Synthesis Ionic Liquids for Chemical and Biochemical Applications

 

　

　
Selected Publications 代表著作  [SCOPUS論文統計]

  • Huang, H.-H.; Jia, J.; Ren, L.; Wang, S.; Yue, T.;* Yan, B.;* Chu, Y.-H.* "A Zwitterionic Solution for Smart Ionic Liquids to Evade Cytotoxicity", J. Hazard. Mater. 2023, 453, 131430; DOI: 10.1016/j.jhazmat.2023.131430.
  • Chu, Y.-H.;* Chen, P.-H.; Huang, H.-H. "Exploiting a-Benzylated 1,4-Butanesultones to Expedite the Discovery of Small-Molecule, LCST-type Sulfobetaine Zwitterionic Materials", Mater. Adv. 2023, 4, 1740-1745.
  • Chu, Y.-H.;* Chen, C.-Y.; Chen, J.-S. "Structural Engineering and Optimization of Zwitterionic Salts for Expeditious Discovery of Thermoresponsive Materials", Molecules 2022, 27, 257; DOI: 10.3390/molecules27010257.
  • Pan, X.; Li, L.; Huang, H.-H.; Wu, J.; Zhou, X.; Yan, X.; Jia, J.; Yue, T.;* Chu, Y.-H.;* Yan, B.* "Biosafety-Inspired Structural Optimization of Triazolium Ionic Liquids Based on Structure-Toxicity Relationships", J. Hazard. Mater. 2022, 424, 127521; DOI: 10.1016/j.jhazmat.2021.127521.
  • Wei, P.; Pan, X.; Chen, C.-Y.; Li, H.-Y.; Yan, X.; Li, C.; Chu, Y.-H.;* Yan, B.* "Emerging Impacts of Ionic Liquids on Eco-Environmental Safety and Human Health", Chem. Soc. Rev. 2021, 50, 13609-13627; DOI: 10.1039/d1cs00946j.
  • Chu, Y.-H.;* Chen, C.-Y. "Structural Fine-tuning of Zwitterionic Salts for the Discovery of LCST-type Thermoresponsive Materials", Mater. Chem. Front. 2021, 5, 7286–7290.
  • Chu, Y.-H.*; Cheng, M.-F.; Chiang, Y.-H. "Combinatorial Discovery of Small-Molecule 1,2,3-Triazolium Ionic Liquids Exhibiting Lower Critical Solution Temperature Phase Transition", Sci. Rep. 2020, 10, 18247; DOI: 10.1038/s41598-020-75392-z. 
  • Chu, Y.-H.*; Hwang, C.-C.; Chen, C.-Y.; Tseng, M.-J. "Combinatorial Discovery of Thermoresponsive Cycloammonium Ionic Liquids", Chem. Commun. 2020, 56, 11855 – 11858.
  • Li, H.-Y.; Chu, Y.-H.* "Reaction-Based Amine and Alcohol Gases Detection with Triazine Ionic Liquid Materials", Molecules 2020, 25, 104; doi:10.3390/molecules25010104.
  • Chang, A.; Li, H.-Y.; Chang, I.-N.; Chu, Y.-H.* "Affinity Ionic Liquids for Chemoselective Gas Sensing", Molecules 2018, 23, 2380; doi:10.3390/molecules23092380. 
  • Chen, C.-Y.; Li, K.-H.; Chu, Y.-H.* "Reactions-Based Detection of Chemical Warfare Agent Mimics with Affinity Ionic Liquids", Anal. Chem. 2018, 90, 8320-8325.
  • Chang, Y.-P.; Chu, Y.-H.* 「Recognition-Based Smart Ionic Liquids」, In Ionic Liquid Devices; Eftekhari, A., Ed.; The Royal Society of Chemistry: Cambridge, UK, 2017; Chapter 10.
  • Li, H.-Y.; Chu, Y.-H.* "Exploiting Solvate Ionic Liquids for Amine Gas Analysis on a Quartz Crystal Microbalance", Anal. Chem. 2017, 89, 5186-5192.
  • Tseng, M.-C.; Yuan, T.-C.; Li, Z.; Chu, Y.-H.* "Crowned Ionic Liquids for Biomolecular Interaction Analysis", Anal. Chem. 2016, 88, 10811-10815.
  • Hsu, T.-H.; Chiang, S.-J.; Chu, Y.-H.* "Quartz Crystal Microbalance Analysis of Diels-Alder Reactions of Alkene Gases to Functional Ionic Liquids on Chips", Anal. Chem. 2016, 88, 10837-10841.
  • Li, H.-Y.; Chen, C.-Y.; Cheng, H.-T.; Chu, Y.-H.* "Exploiting Bicyclic 1,2,3-Triazolium Ionic Liquids for Synthesis of Tryptanthrin and Chemoselective Extraction of Copper(II) Ion and Histidine Containing Peptides", Molecules 2016, 21, 1355.
  • Chang, Y.-P.; Chu, Y.-H.* "Gas Sensing Ionic Liquids on Quartz Crystal Microbalance", Ionic Liquids (Hardy, S., Ed.); InTech: Croatia, EU, 2016 (ISBN 978-953-51-4897-5).
  • Chang, Y.-P., Liu, W.-C.; Tseng, M.-C.; Chu, Y.-H.* "Ionic Liquids Tailored for Reaction-Based Gas Sensing on Quartz Crystal Microbalance", Rev. Anal. Chem. 2015, 34, 77-86.
  • Li, H.-Y.; Hsu, T.-H.; Chen, C.-Y.; Tseng, M.-C.; Chu, Y.-H.* "Exploring Silver Ionic Liquids for Reaction-Based Gas Sensing on Quartz Crystal Microbalance", Analyst 2015, 140, 6245-6249.
  • Chang, Y.-P.; Chu, Y.-H.* 「Mixture-based combinatorial libraries from small individual peptide libraries: A Case Study on α1-Antitrypsin Deficiency」, Molecules 2014, 19, 6330-6348.
  • Tseng, M.-C.; Lai, P.-Y.; Shi, L.; Li, H.-Y.; Tseng, M.-J.; Chu, Y.-H. 「Synthesis of Batracylin and N-Sulfonamido Analogues in [b-3C-im][NTf2] Ionic Liquid」, Tetrahedron 2014, 70, 2629-2633.
  • Tseng, M.-C.; Chu, Y.-H. 「Reaction-Based Azide Gas Sensing with Tailored Ionic Liquids Measured by Quartz Crystal Microbalance」, Anal. Chem. 2014, 86, 1949-1952.
  • Chang, Y.-P.; Chu, Y.-H. 「Blocking Formation of Large Protein Aggregates by Small Peptides」, Chem. Commun. 2013, 49, 4591-4600.
  • Liu, Y.-L.; Tseng, M.-C.; Chu, Y.-H. 「Sensing Ionic Liquids for Chemoselective Detection of Acyclic and Cyclic Ketone Gases」, Chem. Commun. 2013, 49, 2560-2562.
  • Shi, Y.; Liu, Y.-L.; Lai, P.-Y.; Tseng, M.-C.; Tseng, M.-J.; Li, Y.; Chu, Y.-H. "Ionic Liquids Promote PCR Amplification of DNA", Chem. Commun. 2012, 48, 5325-5327.
  • Cheng, C. I.; Chang, Y.-P.; Chu, Y.-H. "Biomolecular Interactions and Tools for Their Recognition: Focus on the Quartz Crystal Microbalance and Its Diverse Surface Chemistries and Applications", Chem. Soc. Rev. 2012, 41, 1947-1971.
  • Sowmiah, S.; Cheng, C. I.; Chu, Y.-H. "Ionic Liquids for Green Organic Synthesis", Curr. Org. Syn. 2012, 8, 74-95.
  • Tseng, M.-C.; Cheng, H.-T.; Shen, M.-J.; Chu, Y.-H. 「Bicyclic 1,2,3-Triazolium Ionic Liquids: Synthesis, Characterization, and Application to Rutaecarpine Synthesis」, Org. Lett. 2011, 13, 4434-4437.
  • Chen, C.-W.; Tseng, M.-C.; Hsiao, S.-K.; Chen, W.-H.; Chu, Y.-H. "Transimination Reactions in [b-3C-im][NTf2] Ionic Liquid", Org. Biomol. Chem. 2011, 9, 4188-4193.
  • Tseng, M.-C.; Chu, Y.-W.; Tsai, H.-P.; Lin, C.-M.; Hwang, J.; Chu, Y.-H. 「One-Pot Synthesis of Luotonin A and Its Analogues」, Org. Lett. 2011, 13, 920-923.
  • Tseng, M.-C.; Chu, Y.-H. "Chemoselective Gas Sensing Ionic Liquids", Chem. Commun. 2010, 46, 2983-2985.
  • Tseng, M.-C.; Yang, H.-Y.; Chu, Y.-H. "Total Synthesis of Asperlicin C, Circumdatin F, Demethylbenzomalvin A, Demethoxycircumdatin H, Sclerotigenin, and Other Fused Quinazolinones", Org. Biomol. Chem. 2010, 8, 419-427.
  • Tseng, M.-C.; Tseng, M.-J.; Chu, Y.-H. "Affinity Ionic Liquid", Chem. Commun. 2009, 7503-7505.
  • Sowmiah, S.; Srinivasadesikan, V.; Tseng, M.-C.; Chu, Y.-H. "On the Chemical Stabilities of Ionic Liquids" (invited review), Molecules 2009, 14, 3780-3813.
  • Tseng, M.-C.; Lai, C.-Y.; Chu, Y.-W.; Chu, Y.-H. "Tin Triflate-Mediated Total Syntheses of Circumdatin F, Asperlicin C, Sclerotigenin, and Other Quinazolino[3,2-a][1,4]benzodiazepines", Chem. Commun. 2009, 445-447.
  • Chang, Y.-P.; Mahadeva, R.; Chang, W.-S. W.; Lin, S.-C.; Chu, Y.-H. "Small-Molecule Peptides Inhibit Z α1-Antitrypsin Polymerization ", J. Cell. Mol. Med. 2009, 13, 2304-2316.
  • Tseng, M.-C.; Chu, Y.-H. "Zinc Triflate-Catalyzed Synthesis of Pyrazino[2,1-b]quinazoline-3,6-diones", Tetrahedron 2008, 64, 9515-9520.
  • Tseng, M.-C.; Kan, H.-C,; Chu, Y.-H. "Reactivity of Trihexyl(tetradecyl)phosphonium Chloride, a Room-Temperature Phosphonium Ionic Liquid", Tetrahedron Lett. 2007, 48, 9085-9089.
  • Lin, Y.-L.; Cheng, J.-Y.; Chu, Y.-H. "Microwave-Accelerated Claisen Rearrangement in Bicyclic Imidazolium [b-3C-im][NTf2] Ionic Liquid", Tetrahedron 2007, 63, 10949-10957.
  • Tseng, M.-C.; Chang, Y.-P.; Chu, Y.-H. "Quantitative Measurements of Vancomycin Binding to Self-Assembled Peptide Monolayers on Chips by Quartz Crystal Microbalance", Anal. Biochem. 2007, 371, 1-9.
  • Kan, H.-C,; Tseng, M.-C.; Chu, Y.-H. "Bicyclic Imidazolium-Based Ionic Liquids: Synthesis and Characterization", Tetrahedron. 2007, 63, 1644-1653.
  • 張怡斌、曾明中、朱延和 「生醫感測科技於新藥開發的應用」, 科儀新知 2007, 28, 56-67.
  • Chang, Y.-P.; Tseng, M.-J.; Chu, Y.-H. "Using Surface Plasmon Resonance to Directly Measure Slow Binding of Low Molecular Mass Inhibitors to a VanX Chip", Anal. Biochem. 2006, 359, 63-71.
  • Hsieh, M.-L.; Tseng, M.-J.; Tseng, M.-C.; Chu, Y.-H. "Identification of a New Chromophoric Substrate in the Library of Amino Acid p-Nitroanilides for Continuous Assay of VanX, a D, D-Dipeptidase Essential for Vancomycin Resistance", Anal. Biochem. 2006, 354, 104-110.
  • Cheng, J.-Y.; Chu, Y.-H. "1-Butyl-2,3-trimethyleneimidazolium Bis(trifluoromethylsulfonyl)imide ([b-3C-im][NTf2]): A New, Stable Ionic Liquid", Tetrahedron Lett. 2006, 47, 1575-1579.
  • Chang, Y.-P.; Mahadeva, R.; Chang, W.-S. W.; Shukla, A.; Dafforn, T. R.; Chu, Y.-H. "Identification of a 4-mer Peptide Inhibitor that Effectively Blocks the Polymerization of Pathogenic Z a1-Antitrypsin", Am. J. Respir. Cell Mol. Biol. 2006, 35, 540-548.
  • 張怡斌、張文祥、朱延和 "a1-抗胰蛋白酶缺乏癥與蛋白質構型變異疾病", 化學 2005, 63, 419-430.
  • Cheng, C. I.; Chang, Y.-P.; Chu, Y.-H. "Inhibition of the Pathogenic Polymerization of Z α1-antitrypsin by 4-mer Peptides", Proceedings of the TTT2005 Academic Conference, pp. 8-13 (2005).
  • Tseng, M.-C.; Liang, Y.-M.; Chu, Y.-H. "Synthesis of Fused Tetrahydro-b-carbolinequinoxalinones in 1-n-Butyl-2,3-dimethylimidazolium Bis(trifluoromethylsulfonyl)imide ([bdmim][Tf2N]) and 1-n-Butyl-2,3-dimethylimidazolium Perfluorobutylsulfonate ([bdmim][PFBuSO3]) Ionic Liquids", Tetrahedron Lett. 2005, 46, 6131-6136.
  • Chang, Y.-P.; Chu, Y.-H. "Using Surface Plasmon Resonance to Directly Determine Binding Affinities of Combinatorially Selected Cyclopeptides and Their Linear Analogs to a Streptavidin Chip", Anal. Biochem. 2005, 340, 74-79.
  • Tseng, M.-C.; Chu, Y.-H. "Using Surface Plasmon Resonance to Directly Identify Molecules in a Tripeptide Library that Bind Tightly to Immobilized Vancomycin", Anal. Biochem. 2005, 336, 172-177.