Date of employment: Aug. 1, 2008

Specialty: Organic Synthesis Chemistry

TEL (O): (886-5) 272-0411 ext. 66417

Email: chedsh@ccu.edu.tw

Lab Webpage

B.S. in Chemistry, Tunghai University, 1995

M.S. in Chemistry, National Tsing Hua University, 1997

Ph.D. in Chemistry, National Tsing Hua University, 2003

Postdoctoral Fellow, Tokyo Institute of Technology, 2003 - 2005

Postdoctoral Fellow, National Tsing Hua University, 2005 - 2006

Postdoctoral Fellow, University of Cambridge, 2006 - 2008

Assistant Professor, National Chung Cheng University, 2008- 2013

 Associate Professor, 2013-2020

 Professor, National Chung Cheng University, 2020-

Research Interests

Developing new synthetic methods.

Asymmetric synthesis.

Total synthesis of natural products.

• Hsu, D.-S.*; Hwang, T.-Y. 「Stereoselective Formal Synthesis of Platencin,」 ChemistrySelect 2022, 7, e202103794.
• Hsu, D.-S.*; Wang, M.-Y.; Huang, J.-Y. 「Asymmetric Total Syntheses of (+)-5-epi-Schisansphenin B and the Proposed Structure of (+)-15-Hydroxyacora-4(14),8-diene,」 J. Org. Chem. 2022, 87, 644–651.
• Jillella, R.; Raju, S.; Hsiao, H.-C.; Hsu, D.-S.; Chuang, S.-C. 「Pd-Catalyzed Redox-Neutral C−N Coupling Reaction of Iminoquinones with Electron-Deficient Alkenes without External Oxidants: Access of Tertiary (E)-Enamines and Application to the Synthesis of Indoles and Quinolin-4-ones,」Org. Lett. 2020, 22, 6252–6256.
• Chang, T.-C.; Chiang, C.-Y.; Lin, M.-H.; Chen, I.-K.; Chau, L.-K.*; Hsu, D.-S.*; Shieh, S.-S.; Kuo, C.-J.; Wang, S.-C.; Chen, Y.-F. 「Fiber Optic Particle Plasmon Resonance Immunosensor for Rapid and Sensitive Detection of Methamphetamine Based on Competitive Inhibition,」 Microchem. J. 2020, 157, 105026.
• Hsu, D.-S.; Liang, S.-P. 「NHC-Mediated Synthesis of Tricyclic Spirocarbocycles via an Intramolecular Stetter Reaction of Cyclic Enal-Enones,」J. Org. Chem. 2020, 85, 1270–1278.
• Hsu, D.-S.; Huang, J.-Y. 「Total Synthesis and Determination of the Absolute Configuration of Parimycin,」Org. Lett. 2019, 21, 7665–7668.
• Hsu, D.-S.; Cheng, C.-Y. 「Construction of Spirofused Tricyclic Frameworks by NHC-Catalyzed Intramolecular Stetter Reaction of a Benzaldehyde Tether with a Cyclic Enone,」 J. Org. Chem. 2019, 84, 10832–10842.
• Hsu, D.-S.; Hwang, T.-Y. 「Stereocontrolled Formal Synthesis of Platencin,」 Eur. J. Org. Chem. 2018, 4689–4695.
• Hsu, D.-S.; Liou, C.-Y.; 「Total Synthesis and Structural Revision of (±)-Nidemone,」 Org. Biomol. Chem. 2018, 16, 4990–4995.
• Hsu, D.-S.; Yeh, J.-Y.; Cheng, C.-Y. 「Total Synthesis of the Proposed Structure of (±)-Nidemone,」 Org. Lett. 2017, 19, 5549–5552.
• Weng, C.-H.; Hsu, D.-S.; Liao, C.-C. 「Application of Carbohydrate-Templated Asymmetric Diels-Alder Reaction to the Syntheses of ent-Penicillones A and B,」 J. Org. Chem. 2016, 81, 11421–11426.
• Cheng, Y.-J.; Yu, S.-Y.; Lin, S.-C.; Lin, J. T.; Chen, L.-Y.; Hsiu, D.-S.; Wen, Y. S.; Lee, M. M.; Sun, S.-S. 「A Phenothiazine/dimesitylborane Hybrid Material as a Bipolar Transport Host of Red Phosphor,」 J. Mater. Chem. C 2016, 4, 9499–9508.
• Chuang, S.-C.; Sung, S.-P.; Deng, J.-C.; Chioua, M.-F.; Hsu, D.-S. 「Multicomponent Reactions of Phosphines, Enynedioates and Benzylidene Malononitriles Generated Highly Substituted Cyclopentenes through an Unexpected Phosphine α-Addition-δ-Evolvement of an Anion Pathway,」 Org. Biomol. Chem. 2016, 14, 2306–2317.
• Hsu, D.-S.; Chen, C.-H.; Hsu, C.-W. 「Synthesis of Spiranes by Thiol-Mediated Acyl Radical Cyclization,」 Eur. J. Org. Chem. 2016, 589–598.
• Lu, Y.-B.; Hsu, D.-S.; Liao, C.-C. 「Rapid Construction of Polycyclic Ring Systems from Aromatics: Stereoselective Synthesis of the Carbon Framework of Vinigrol,」 Tetrahedron Lett. 2014, 55, 5315–5318.
• Kraus, H.; Français, A.; O』Brien, M.; Frost, J.; Diéguez-Vázquez, A.; Polara, A.; Baricordi, N.; Horan, R.; Hsu, D.-S.; Tsunoda, T.; Ley, S. V. 「Synthesis of Spongistatin 2 Employing a New Route to the EF Fragment,」 Chem. Sci. 2013, 4, 1989–1994.
• Kitamura, K.; Shigeta, M.; Maezawa, Y.; Watanabe, Y.; Hsu, D.-S.; Yoshio, A.; Matsumoto, T.; Suzuki, K. 「Preparation of L-Vancosamine-related Glycosyl Donors,」 J. Antibiot 2013, 66, 131–139.
• Hsu, D.-S.; Juo, B.-C. 「Intramolecular Reductive Cyclization of an Enone-aldehyde: A New Approach to the Synthesis of (±)-Majusculone,」  Tetrahedron Lett. 2013, 54, 1751–1753.
• Hsu, D.-S.; Lin, S.-C. 「Total Syntheses of Cladoacetals A and B: Confirmation of Absolute Configurations,」 J. Org. Chem. 2012, 77, 6139–6146.
• Hsu, D.-S.; Hsu, C.-W. 「Spiranes Synthesis Based on Samarium Diiodide-Mediated Reductive Cyclization,」 Tetrahedron Lett. 2012, 53, 2185–2188.
• Hsu, D.-S.; Huang, C.-Y. 「Room-Temperature B(OAc)3-Promoted Diels-Alder Reaction of Juglone with Styrenes. Total Syntheses of Tetrangulol and Anhydrolandomycinone,」 J. Org. Chem. 2012, 77, 2659–2666.
• Ben, A.; Hsu, D.-S.; Matsumoto, T.; Suzuki, K. "Total Synthesis and Structure Revision of Deacetylravidomycin M" Tetrahedron 2011, 67, 6460–6468.
• Hsu, D.-S.; Chou, Y.-Y.; Tung, Y.-S.; Liao, C.-C. "Photochemistry of
• Tricyclo[5.2.2.02,6]undeca-4,10-dien-8-ones: An Efficient General Route to Substituted Linear Triquinanes from 2-Methoxyphenols. Total Synthesis of (+/-)-Δ9(12)-Capnellene" Chem. Eur. J. 2010, 16, 3121–3131.
• Hsu, D.-S.; Hsu, P.-Y.; Lee, Y.-C.; Liao, C.-C. 「Stereocontrolled Synthesis of Polyfunctionalized cis-Decalins from 2-Methoxyphenols. Total Syntheses of (±)-Eremopetasidione, (±)-3β-Angeloyloxyfuranoeremophilane and (±)-3β- Methacryloyloxyfuranoeremophilane,」 J. Org. Chem. 2008, 73, 2554–2563.
• O』Brien, M.; Diéguez-Vázquez, A.; Hsu, D.-S.; Kraus, H.; Sumino, Y.; Ley, S. V. 「Azeotropic Reflux Chromatography: An Efficient Solution to a Difficult Separation in the Scale-up Synthesis of Spongistatin 1,」 Org. Biomol. Chem. 2008, 6, 1159–1164..
• Hsu, D.-S.; Liao, C.-C. 「First Total Syntheses of (±)-Penicillones A and B,」 Org. Lett. 2007, 9, 4563–4565.
• Hsu, D.-S.; Matsumoto, T.; Suzuki, K. 「Concise Synthesis of (±)-γ- Indomycinone,」 Chem. Lett. 2006, 35, 1016–1017.
• Hsu, D.-S.; Matsumoto, T.; Suzuki, K. 「Synthesis of L-Vancosamine Derivatives from Methyl α-D-Mannopyranoside,」 Synlett 2006, 469–471.
• Hsu, D.-S.; Matsumoto, T.; Suzuki, K. 「Efficient Synthetic Route to Ravidosamine Derivatives,」 Synlett 2005, 801–804.
• Hsu, D.-S.; Liao, C.-C. 「Total Syntheses of Sesterpenic Acids: Refuted (±)-Bilosespenes A and B,」 Org. Lett. 2003, 5, 4741–4743.
• Hsu, D.-S.; Hsu, P.-Y.; Liao, C.-C. 「The First Total Synthesis of (±)-Eremopetasidione,」 Org. Lett. 2001, 3, 263–265.
• Hsu, D.-S.; Rao, P. D.; Liao, C.-C. "Short and Efficient Route to Substituted Linear Triquinanes," Chem. Commun. 1998, 1795–1796.