Date of employment: Feb. 1, 2023

Specialty:

Physical chemistry,

Structural biology

Computational Biophysics

TEL (O): (886-5) 272-0411 ext. 66401

Email: myt@ccu.edu.tw

Lab Webpage

到校日期：112年2月1日

專長領域：

物理化學

結構生物

計算生物物理

聯絡電話：(05) 272-0411 ext. 66401

電子信箱：myt@ccu.edu.tw

研究室：Rm 416

實驗室網頁

B.S.in Chemistry, National Taiwan Normal University, 2005

Ph.D. in Physical Chemistry, National Taiwan University, 2011

R&D Fellow (Alternative Military Duty), National Chiao Tung University, 2011-2014

Postdoc Research Associate, Rice University, 2014-2018

Assistant Professor, Tamkang University, 2018-2023.1

Assistant Professor, National Chung Cheng University, 2023.2-

學士 國立臺灣師範大學化學系學士 (2005)

博士 國立臺灣大學化學研究所博士 (2011)

國立交通大學應用化學系研發替代役 (2011-2014)

美國萊斯大學博士後研究(2014-2018)

私立淡江大學化學系助理教授 (2018-2023.1)

國立中正大學化生系助理教授 (2023.2-)

Research Interests

Use Molecular Dynamics simulation to study disease related biomolecular condensates/aggregates

Theoretical modeling of gene regulation and binding recognition

Develop data-driven predictive models

Use statistical thermodynamics to study multivalent interactions in liquid-liquid phase separation(LLPS)

研究重點

以分子動力學模擬方法研究疾病相關的生物分子凝聚體/聚集物

基因調控以及結合辨識的理論建模

開發數據驅動之化學預測模型

液態-液態相轉變（多價作用）的統計熱力學

• Lin, T.-Y.; Ma, Y.-W.; Tsai, M.-Y.* Early-stage Oligomerization of Prion-like Polypeptides Reveals the Molecular Mechanism of Amyloid-disrupting Capacity by Proline Residues. J. Phys. Chem. B. (Accepted)
• Chen, X.; Tsai, M.-Y.*; Wolynes, P. G.* The Role of Charge Density Coupled DNA Bending in Transcription Factor Sequence Binding Specificity: A Generic Mechanism for Indirect Readout. J. Am. Chem. Soc. 2022, 144 (4), 1835–1845.
• Ma, Y.-W.; Lin, T.-Y.; Tsai, M.-Y.* Fibril Surface-dependent Amyloid Precursors revealed by Coarse-grained Molecular Dynamics Simulation. Front. Mol. Biosci. 2021, 8, 719320.
• Tsai, M.-Y.*,†; Shen, J.-L.†; Schafer, N. P.; Wolynes, P. G.*, Modeling Protein Aggregation Kinetics: The Method of Second Stochasticization. J. Phys. Chem. B. 2021, 125 (4), 1118–1133.
• Tsai, M.-Y.; Zheng, W; Chen, M.; Wolynes, P. G.* Multiple Binding Configurations of Fis Protein Pairs on DNA: Facilitated Dissociation versus Cooperative Dissociation. J. Am. Chem. Soc. 2019, 141 (45), 18113−18126.
• Tsai, M.-Y.; Zhang, B.; Zheng, W.; Wolynes, P. G.* Molecular Mechanism of Facilitated Dissociation of Fis Protein from DNA. J. Am. Chem. Soc. 2016, 138 (41), 13497−13500.
• Zheng, W.; Tsai, M.-Y.; Wolynes, P. G.* Comparing the Aggregation Free Energy Landscapes of Amyloid Beta(1-42) and Amyloid Beta(1-40). J. Am. Chem. Soc. 2017, 139 (46), 16666–16676.
• Zheng, W.; Tsai, M.-Y.; Chen, M.; Wolynes, P. G.* Exploring the Aggregation Free Energy Landscape of the Amyloid-β Protein (1-40). Proc. Natl. Acad. Sci. U. S. A. 2016, 113 (42), 11835–11840.
• Tsai, M.-Y.; Zheng, W.; Balamurugan, D.; Schafer, N. P.; Kim, B. L.; Cheung, M. S.; Wolynes, P. G.* Electrostatics, Structure Prediction, and the Energy Landscapes for Protein Folding and Binding. Protein Sci. 2016, 25 (1), 255–269.
• Tsai, M.-Y.*; Yuan, J.-M.; Teranishi, Y.; Lin, S. H. Thermodynamics of Protein Folding Using a Modified Wako-Saitô-Muñoz-Eaton Model. J. Biol. Phys. 2012, 38 (4), 543–571.