林群欽 副教授

　　
Date of employment: Aug. 1, 2018
Specialty:
Magnetic resonance spectroscopy and imaging
Physical chemistry
Biophysics
TEL (O): (886-5) 272-0411 ext. 66418
Email:cheel@ccu.edu.tw
 
 
到校日期：107年8月1日
專長領域：
    核磁共振光譜影像
    物理化學
    生物物理
聯絡電話：05-2720411 ext. 66418
電子信箱：cheel@ccu.edu.tw
研究室：Rm 404
 
 
 
B.S. in Applied Chemistry, National Chi Nan University, 2006
M.S. in Chemistry, National Chung Hsing University, 2008
Ph.D in Chemistry and Biochemistry, University of California, San Diego, 2015
Postdoc Fellow, Vanderbilt University Institute of Imaging Science, 2015-2018
Assistant Professor, National Chung Cheng University, 2018-2023
Associate Professor, National Chung Cheng University, 2023-
 
　
 
學士 國立暨南國際大學應用化學系學士 (2006)
 
碩士 國立中興大學化學系碩士 (2008)
 
博士 美國加州大學聖地牙哥分校化學暨生物化學系博士 (2015)
 
美國范德堡大學影像科學中心博士後研究 (2015-2018)
 
國立中正大學化生系助理教授 (2018-2023)
 
國立中正大學化生系副教授 (2023-)
 
Research Interests
Developing techniques of magnetic
resonance spectroscopy and imaging
Studying membrane proteins with NMR
Diagnosis diseases with CEST (chemical exchange saturation transfer) MRI
Applications of biological and medical imaging 
　
　
研究重點
開發核磁共振光譜影像技術
以核磁共振光譜研究膜蛋白
以化學交換飽和核轉移磁共振影像診斷疾病
生物醫學影像應用
Selected Publications 代表著作  [SCOPUS論文統計]
  • Chou, S.-W.; Chen, T.-H.; Fa, Y.-C.; Yang, Y.-Y.; Lin, C.-Y.; Kuo, K.-L.; Wu, S.-T.; Lin, E. C.*; Ho, J.-A. A.*; Hsiao, J.-K.*; Chou, P.-T.* “Gadolinium-Engineered Magnetic Alloy Nanoparticles for Magnetic Resonance T1/T2 Dual-Modal and Computed Tomography Imaging”, Chem. Mater., 2022, 34(22), 10050-10058
  • Lin, E. C.*; Chen T.-H.; Chen P.-C.; Liao M.-Y. “Charge order and structure transformation of hydrated cesium cobaltates revealed by variable-temperature 133Cs NMR spectroscopy.”, J. Chin. Chem. Soc., 2022, 69(9), 1552-1557
  • Wu, W.-F.; Shen, C.-W; Lai, K.-M.; Chen, Y.-J.; Lin, E. C.*; Chen C.-C.*, “The Application of DTCWT on MRI-Derived Radiomics for Differentiation of Glioblastoma and Solitary Brain Metastases.” J. Pers. Med., 2022, 12(8), 1276
  • Wu, Q.-X.; Liu, H.-Q.; Wang, Y.-J.; Chen, T.-C.; Wei, Z.-Y.; Chang, J.-H.; Chen, T.-H.; Seema, J.; Lin, E. C.* “Chemical Exchange Saturation Transfer (CEST) Signal at −1.6 ppm and Its Application for Imaging a C6 Glioma Model.” Biomedicines, 2022, 10(6), 1220
  • Wu, S.‐T.; Chen, P.‐C.; Tseng, Y.‐H.; Chen, T.‐H.; Wang, Y.‐J.; Tsai, Z.‐L.; Tsai, Lin, E. C.* “Assessment of Cellular Responses in Three‐Dimensional Cell Cultures Through Chemical Exchange Saturation Transfer and 1H Magnetic Resonance Spectroscopy.” NMR in Biomed., 2022, 35, e4757.
  • Huang, Y.-T.; Su, Y.-C.; Wu, H.-R.; Huang, H.-H.; Lin, E. C.; Tsai, T.-W.; Tseng, H.-W.; Fang, J.-L.; Yu, C.-C. “Sulfo-Fluorous Tagging Strategy for Site-Selective Enzymatic Glycosylation of para-Human Milk Oligosaccharides.” ACS Catal., 2021, 11, 2631-2643
  • Zu, Z.; Lin, E. C.; Louie, E. A.; Jiang, X; Lankford, C. L.; Damon, B.; Does, M. D.; Gore, J. C.; Gochberg, D. F. “Chemical exchange rotation transfer imaging of phosphocreatine in muscle.” NMR in Biomed., 2021, 34, e4437.
  • Chen, Y.-W.; Liu, H.-Q.; Wu, Q.; Huang, Y.-H.; Tung, Y.-Y.; Lin, M.-H.; Lin, C.-H.; Chen, T.-C.; Lin, E. C.; Hwang, D. W. “pH Mapping of Skeletal Muscle by Chemical Exchange Saturation Transfer (CEST) Imaging.” Cells, 2020, 9, 2610.
  • Wen, X.; Ou, Y.-C.; Bogatcheva, G.; Thomas, G.; Mahadevan-Jansen, A.; Singh, B.; Lin, E. C.; Bardhan, R. “Probing metabolic alterations in breast cancer in response to molecular inhibitors with Raman spectroscopy and validated with mass spectrometry.” Chem. Sci. 2020, 11, 9863-9874.
  • Chang, Y.‐C.; Liu, H.‐Q.; Chang, J.‐H.; Chang, Y.‐Y.; Lin, E. C.* “Role of the cholesterol hydroxyl group in the chemical exchange saturation transfer signal at − 1.6 ppm.” NMR in Biomed., 2020, 33, e4356.
  • Wen, X.; Ou, Y.‐C.; Zarick, H. F.; Zhang, X.; Hmelo, A. B.; Victor, Q. J.; Paul, E. P.; Slocik, J. M.; Naik, R. R.; Bellan, L. M.; Lin, E. C.; Bardhan R. “PRADA: Portable Reusable Accurate Diagnostics with nanostar Antennas for Multiplexed Biomarker Screening.” Bioeng. Transl. Med., 2020, 5, e10165.
  • Zu, Z.; Lin, E. C.; Louie, E. A.; Xu, J.; Li, H.; Xie, J.; Lankford, C. L.; Chekmenev, E. Y.; Swanson, S. D.; Does, M. D.; Gore, J. C.; Gochberg, D. F. “Relayed nuclear Overhauser enhancement sensitivity to membrane Cho phospholipids.” Magn. Reson. Med. 2020, 84, 1961-1976.
  • Ou, Y.-C.; Wen, X.; Johnson, C. A.; Shae, D.; Ayala, O. D.; Webb, J. A.; Lin, E. C.; DeLapp, R. C.; Boyd, K. L.; Richmond, A.; Mahadevan-Jansen, A.; Rafat, M.; Wilson, J. T.; Balko, J. M.; Tantawy, M. N.; Vilgelm, A. E.; Bardhan, R. “Multimodal multiplexed immunoimaging with nanostars to detect multiple immunomarkers and monitor response to immunotherapies.” ACS nano, 2019, 14, 651-663.
  • Ou, Y.-C.; Webb, J. A.; O’Brien, C. M.; Pence, I. J.; Lin, E. C.; Paul, E. P.; Cole, D.; Ou, S.-H.; Lapierre-Landry, M.; DeLapp, R. C.; Lippmann, E. S.; Mahadevan-Jansen, A.; Bardhan R. “Diagnosis of immunomarkers in vivo via multiplexed surface enhanced Raman spectroscopy with gold nanostars.” Nanoscale. 2018, 10, 13092-13105.
  • Lin, E. C.; Li, H.; Zu, Z.; Lankford, C. L.; Dortch, R. D.; Gore, J. C.; Gochberg D. F. “Chemical exchange rotation transfer (CERT) on human brain at 3 Tesla.” Magn. Reson. Med. 2018, 80, 2609-2617.
  • Zhang, C.; Idelbayev, Y.; Tao, Y.; Duggan, B. M.; Lin, E. C.; Gerwick, E. C.; Cottrell, G. W.; Gerwick, W. H. “Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Research.” Sci. Rep. 2017, 7, 14243.
  • Webb, J. A.; Ou, Y.-C.; Faley, S.; Hittinger, J.; Cutright, C. C.; Lin, E. C.; Bellan, L. M.; Bardhan, R. “Theranostic Gold Nanoantennas for Simultanoeus Multiplexed Raman Imaging and Photothermal Therapy.” ACS Omega 2017, 2, 3583-3594.
  • Zhang, X.-Y.; Xie, J.; Wang, F.; Lin, E. C.; Xu, J.; Gochberg, D. F.; Gore, J. C.; Zu, Z. “Assignment of the molecular origins of CEST signals at 2 ppm in rat brain.” Magn. Reson. Med. 2017, 78, 881-887.
  • Zu, Z.; Louie, E. A.; Lin, E. C.; Jiang, X.; Does, M. D.; Gore, J. C.; Gochberg, D. F. “Chemical Exchange Rotation Transfer Imaging of Intermediate Exchanging Amines at 2 ppm.” NMR in Biomed. 2017, 30, e3756.
  • Zhang, H.; Lin, E. C.; Das, B. B.; Tian, Y.; Opella, S. J. “Structural determination of virus protein U from HIV-1 by NMR in membrane environments.” BBA-BIOMEMBRANES 2015, 1848, 3007-3018.
  • Lin, E. C.; Opella, S. J. “Covariance Spectroscopy in High-Resolution Multi-dimensional Solid-state NMR.” J. Magn. Reson. 2014, 239, 57-60.
  • Lin, E. C.; Opella, S. J. “Sampling Scheme and Compressed Sensing Applied to Solid-State NMR Spectroscopy.” J. Magn. Reson. 2013, 237, 40-48.
  • Das, B. B.; Lin, E. C.; Opella, S. J. “Experiments Optimized for Magic Angle Spinning and Oriented Sample Solid-State NMR of Proteins.” J. Phys. Chem. B 2013, 117, 12422-12431.
  • Hsu, C.-C.; White, N. M.; Hayashi, M.; Lin, E. C.; Poon, T.; Banerjee, I.; Chen, J.; Pfaff, S. L.; Macagno, E. R.; Dorrestein, P. C. “Microscopy ambient ionization top-down mass spectrometry reveals developmental patterning.” Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 14855-14860.
  • Chien, M.-P.; Thompson, M. P.; Lin, E. C.; Gianneschi, N. C. “Fluorogenic Enzyme-Responsive Micellar Nanoparticles.” Chem. Sci. 2012, 3, 2690-2694.
  • Lin, E. C.; Opella, S. J. “1H assisted 13C/15N heteronuclear correlation spectroscopy in oriented sample solid-state NMR of single crystal and magnetically aligned samples.” J. Magn. Reson. 2011, 211, 37-44.
  • Lin, E. C.; Wu, C. H.; Yang, Y.; Grant, C. V.; Opella, S. J. “1H-13C separated local field spectroscopy of uniformly 13C labeled peptides and proteins.” J. Magn. Reson. 2010, 206, 105-111.
  • Tang, H.-Y.; Lin, C.-C.; Wang, L.-S.; Yang, W.-C.; Liao, K.-H.; Li, F.-Y.; Liao, M. Y. “Quantum size effect on 67Zn-NMR measurements of ZnS nanoparticles.” Phys. Rev. B 2008, 77, 165420-165425.