洪永叁 教授 Yung-Son Hon                                 Professor

Date of employment: Aug. 1, 1995

Specialty: Synthetic Organic Chemistry, Medicinal Chemistry

TEL (O): (886-5) 272-0411 ext. 66412

Email: cheysh@ccu.edu.tw

Lab Webpage

 

到校日期:8481

專長領域:有機合成化學,藥物合成

 

聯絡電話:05-2720411 ext. 66412

電子信箱:cheysh@ccu.edu.tw

研究室:Rm 504

實驗室網頁

 

 

B.S. in Chemistry, National Chung Hsing University, 1977

M.S. in  Chemistry, National Hsing Hua University, 1979

Ph.D. in  Chemistry, Iowa State University, 1981-1985

Postdoc Fellow, Harvard Univ., 1985-1986

Postdoc Fellow, Indiana Univ., 1986-1987

Assoc. Research Fellow, 1987-1993

Research Fellow (1993-1995), Institute of Chemistry, Academia Sinica

Professor, National Chung Cheng University, 1995-

Adjunct Research Fellow, Academia Sinica, 2001-

Visiting Scholar, RIKEN, Japan, 2005/8-2006/2

 

 

 

學士 國立中興大學化學系理學士 (1977)

碩士 國立清華大學應用化學所碩士 (1979)

博士 美國愛荷華州立大學有機化學博士 (1981-1985)

美國哈佛大學博士後研究員 (1985-1986)

美國印第安那大學博士後研究員 (1986-1987)

中央研究院化學研究所副研究員 (1987-1993)

中央研究院化學研究所研究員 (1993-1995)

國立中正大學化學系教授 (1995-)

中央研究院化學所合聘研究員 (2001-)

日本理化學研究所訪問學者 (2005/8-2006/2

 

Research Interests

Develop New Reagents and Methodologies in Organic Synthesis.

Synthesis of Natural Products or Compounds with Biological Activity, Fluorescence Property.

 

 

研究重點

開發新合成試劑與方法,以建構新奇分子骨架

合成具生物活性之天然物藥物合成

合成高螢光性化合物與其應用

Selected Publications 代表著作

  • Hon, Y. S.; Chen, H. F. “4-endo-Hydroxy-2-oxabicyclo[3.30]oct-7-en-3-one as a Useful
    Building Block in the Formal Total Synthesis of Furofurandione Natural Products”,
    Tetrahedron Lett.
    2007, 48, 8611-8614.

  • Hon, Y. S.; Wong, Y. C.; Chang, C. P.; Hsieh, C. H. “Tishchenko Reactions of Aldehydes
    Promoted by Diisobutylaluminum Hydride and its Application to the Macrocyclic Lactone
    Formation”,
    Tetrahedron 2007, 63, 11325-11340.

  • Hon, Y. S.; Hsieh, C. H. “Dibromethane as One-carbon Source in Organic Synthesis: Total
    Synthesis of (±)-Canadensolide”,
    Tetrahedron 2006, 62, 9713-9717.

  • Hon, Y. S.; Chang, C. P. “Organozinc Alkoxide-promoted Aldol-Tishchenko Reaction of
    Aliphatic Aldehydes: An Expedient Entry to Prepare the
    a-Methylene Ketones”,
    Tetrahedron
    2005, 61, 5267-5275.

  • Hon, Y. S.; Hsieh, C. H.; Liu, Y. W. “Dibromethane as One-carbon Source in Organic Synthesis:
    Total Synthesis of (±)- and (-)-Methylenelactocin”,
    Tetrahedron 2005, 61, 2713-2723.

  • Hon, Y. S.; Wong, Y. C. “Synthetic Applications of the Amine-base Treatment in the Ozonolysis
    of Substituted-allyl Silyl Ethers or -Allyl Esters via a Novel Ene
    -diol Rearrangement”,
    Tetrahedron Lett.
    2005, 46, 1365-1368.

  • Wu, K. C.; Lin, Y. S.; Yeh, Y. S.; Ahmed, M. O.; Hon, Y. S.; Chou, P. T. “Design and synthesis of
    dual intramolecular hydrogen bonding systems: their application in metal cation sensing based
    on excited state proton transfer reaction”, Tetrahedron 2004, 60, 11861-11868.

  • Hon, Y. S.; Liu, Y. W.; Hsieh, C. H. “Dibromethane as One-carbon Source in Organic Synthesis:
    A Versatile Methodology to Prepare the Cyclic and Acyclic
    a-Methylene or a-Keto acid
    Derivatives from the Corresponding Terminal Alkenes”, Tetrahedron 2004, 60, 4837-4860.

  • Hon, Y. S.; Chang, C. P.; Wong, Y. C. “Tishchenko Reactions and Oppenauer Oxidation
    Reactions of Aldehydes Promoted by Diisobutylaluminium Hydride”, Tetrahedron Lett. 2004,
    45
    , 3313-3315.

  • Wu, K. C. Ahmed, M. O.; Chen, C. Y.; Huang, G. W.; Hon, Y. S.; Chou, P. T. ”8-(1,4,7,10-
    Tetraoxa-13-azacyclopentadec-13-ylmethyl)quinolin-7-ol: Synthesis and Application as a Highly
    Sensitive Metal Cation Probe”, Chem. Commun. 2003, 890-891.

  • Hon, Y. S.; Hsu, T. R.; Chen, C. Y.; Lin, Y. H.; Chang, F. R; Hsieh, C. H.; Szu, P. H.
    “Dibromomethane as One-Carbon Source in Organic Synthesis: Microwave Accelerated

    a
    -Methylenation of Ketones with Dibromomethane and Diethylamine”, Tetrahedron 2003, 59,
    1509-1520.

  • Hon, Y. S.; Wu, K. C. “Polymer-Supported Tertiary Amine in Organic Synthesis: A Useful
    Reagent in the Conversion of Alkenes to Carbonyl Compounds via the Corresponding
    Ozonides”, Tetrahedron 2003, 59, 493-498.

  • Hon, Y. S.; Lee, C. F. “Acetonyltriphenylphosphonium Bromide in Organic Synthesis: A Useful
    Catalyst in the Cyclotrimerization of Aldehydes”, Tetrahedron 2001, 57, 6181-6188.

  • Hon, Y. S.; Lee, C. F.; Chen, R. J.; Szu, P. H. “Acetonyltriphenyl-phosphonium Bromide and its
    Polymer-Supported Analogues as Catalysts in Protection and Deprotection of Alcohols as
    Alkyl Vinyl Ethers”, Tetrahedron 2001, 57, 5991-6001.

  • Hon, Y. S.; Lu, L.; Chang, R. C.; Lin, S. W.; Sun, P. P.; Lee, C. F. “Syntheses of a,b-Unsaturated
    Carbonyl Compounds from the Reaction of Monosubstituted Ozonides with Stable
    Phosphonium Ylides”, Tetrahedron 2000, 56, 9269-9279.

  • Hon, Y. S.; Lee, C. F. “The Reaction of Triphenylphosphonium or Triphenylarsonium Salts with
    Aldehyde: Effect of the Counteranion on their Reactivity”, Tetrahedron 2000, 56, 7893-7902.