游景晴 助理教授 Yu, Ching-Ching                Assistant Professor

Date of employment: Aug. 1, 2015

Specialty: Bioorganic chemistry, Chemical biology, Enzymatic carbohydrate synthesis, Directed evolution

TEL (O): (886-5) 272-0411
ext.
66412

Email: checcyu@ccu.edu.tw

Lab Webpage

 

到校日期:10481

專長領域: 生物有機化學、化學生物學、酵素寡醣合成、酵素定向演化

聯絡電話:05-2720411 ext. 66412

電子信箱:checcyu@ccu.edu.tw

研究室:Rm 504

實驗室網頁

 

B.S. in Chemistry, National Chang Hua University of Education, 2005

M.S. in Chemistry, National Tsing Hua University, 2007

Ph.D. in Chemistry, National Tsing Hua University, 2012

Visiting Doctoral Researcher, Osaka University, 2010

Visiting Doctoral Researcher, University of British Columbia, 2011-2012

Postdoctoral Fellow, National Tsing Hua University, 2013

Postdoctoral Fellow, University of British Columbia, 2014-2015

Assistant Professor, National Chung Cheng University, 2015

 

學士 彰化師範大學化學系理學士 (2005)

國立清華大學化學系碩士 (2007)

博士 國立清華大學化學系博士 (2012)

日本大阪大學訪問研究員 (2010)

加拿大英屬哥倫比亞大學訪問研究員 (2011-2012)

國立清華大學化學系博士後研究員 (2013)

加拿大英屬哥倫比亞大學博士後研究員 (2014-2015)

中正大學化生系助理教授 (2015)

 

 

Research Interests

Total synthesis of glycoprotein

Enzymatic oligosaccharide synthesis

Directed evolution of carbohydrate-active enzymes

研究重點

新穎醣蛋白合成方法開發

酵素寡醣合成

醣類酵素定向演化

Selected Publications 代表著作
  • Gesa Volkers, Liam J Worrall, David H Kwan, Ching-Ching Yu, Lars Baumann, Emilie Lameignere, Gregory A Wasney, Nichollas E Scott, Warren Wakarchuk, Leonard J Foster, Stephen G Withers and Natalie C J Strynadka*, “Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation”, Nature Structural & Molecular Biology, 2015, 22, 627–635.

  • Ching-Ching Yu and Stephen G. Withers*, “Recent Developments in Enzymatic Synthesis of Modified Sialic Acid Derivatives”, Advanced Synthesis & Catalysis, 2015, 357, 1633–1654.

  • Li-De Huang, Avijit Kumar Adak, Ching-Ching Yu, Wei-Chen Hsiao, Hong-Jyune Lin, Mu-Lin Chen, and Chun-Cheng Lin*, “Fabrication of Highly Stable Glyco-Gold Nanoparticles and Development of a Glyco-Gold Nanoparticle-Based Oriented-Immobilized Antibody Microarray for Lectin (GOAL) Assay,” Chemistry – An European Journal, 2015, 21, 3956–3967.

  • Si-Peng Li, Wei-Chen Hsiao, Ching-Ching Yu, Wei-Ting Chien, Hong-Jyune Lin, Li-De Huang, Chien-Hung Lin, Wan-Ling Wu, Shih-Hsiung Wu, and Chun-Cheng Lin*, “Characterization of Meiothermus taiwanensis galactokinase and its uses in the one-pot enzymatic synthesis of uridine diphosphate-galactose and the chemoenzymatic synthesis of the carbohydrate antigen stage specific embryonic antigen-3,” Advanced Synthesis & Catalysis, 2014, 356, 3199–3213.

  • Wei-Ting Chien, Chien-Fu Liang, Ching-Ching Yu, Chien-Hung Lin, Si-Peng Li, Indah Primadona, Yu-Ju Chen, Kwok Kong T. Mong, and Chun-Cheng Lin*, “Sequential one-pot enzymatic synthesis of oligo-N-acetyllactosamine and its multi-sialylated extensions,” Chemical Communications, 2014, 50, 5786–5789.

  • Hsiao-Chan Wang,+ Ching-Ching Yu,+ Chien-Fu Liang, Li-De Huang, Jih-Ru Hwu and Chun-Cheng Lin*, “Site-selective protein immobilization via 2-cyanobenzothiazole-cysteine condensation,” ChemBioChem, 2014, 15, 829–835. +Authors with equal contribution

  • Ching-Ching Yu, Tara Hill, David H. Kwan, Hong-Ming Chen, Chun-Cheng Lin, Warren Wakarchuk, and Stephen G. Withers*, “A plate based high-throughput activity assay for polysialyltransferase from Neisseria meningitidis,” Analytical Biochemistry, 2014, 444, 67–74.

  • Avijit K. Adak, Ching-Ching Yu, Chien-Fu Liang, and Chun-Cheng Lin*, “Synthesis of sialic acid-containing saccharides,” Current Opinion in Chemistry Biology, 2013, 17, 1030–1038.

  • Ching-Ching Yu, Li-De Huang, David Kwan, Warren W. Wakarchuk, Stephen G. Withers*, and Chun-Cheng Lin*, “A glyco-gold nanoparticle based assay for α-2,8-polysialyltransferase from Neisseria meningitidis,” Chemical Communications, 2013, 49, 10166–10168.

  • Po-Chiao Lin*, Ching-Ching Yu, Huan-Ting Wu, Ying-Wei Lu, Chia-Li Han, An-Kai Su, Yu-Ju Chen*, and Chun-Cheng Lin*, “A Chemically Functionalized Magnetic Nanoplatform for Rapid and Specific Biomolecular Recognition and Separation,” Biomacromolecules, 2013, 14, 160–168.

  • Ching-Ching Yu, Yu-Ying Kuo, Chien-Fu Liang, Wei-Ting Chien, Huan-Ting Wu, Tsung-Che Chang, Fan-Dan Jan, and Chun-Cheng Lin*, “Site-specific Immobilization of Enzymes on Magnetic Nanoparticles and Their Use in Organic Synthesis,” Bioconjugate Chemistry, 2012, 23, 714723.

  • Wei-Ting Chien, Chien-Fu Liang, Ching-Ching Yu, Jian- Hong Lin, Huang-Ting Wu, and Chun-Cheng Lin*, “Glucose-1-phosphate Thymidylyltransferase in the Synthesis of UDP-Galactose and its Application in the Synthesis of LacNAc,” Advanced Synthesis & Catalysis, 2012, 354, 123132.

  • Hsuan-Yi Hsiao, Mu-Lin Chen, Huan-Ting Wu, Li-De Huang, Wei-Ting Chien, Ching-Ching Yu, Fan-Dan Jan, Sk Sahabuddin, Tsung-Che Chang and Chun-Cheng Lin*, “Fabrication of carbohydrate microarrays through boronate formation,” Chemical Communications, 2011, 47, 1187–1189.

  • Ching-Ching Yu, + Po-Chiao Lin+ and Chun-Cheng Lin*, “Site-specific immobilization of CMP-sialic acid synthetase on magnetic nanoparticles and its use in the synthesis of CMP-sialic acid,” Chemical Communications, 2008, 1308–1310.  +Authors with equal contribution

  • Po-Chiao Lin, Shau-Hua Ueng, Sheng-Chieh Yu, Mi-Dan Jan, Avijit Kumar Adak, Ching-Ching Yu and Chun-Cheng Lin*, “Surface Modification of Magnetic Nanoparticle via Cu(I)-Catalyzed Alkyne-azide [2 + 3] Cycloaddition,” Organic Letters, 2007, 9, 2131–2134.